OVARIAN DEPLETION: ovarian reserve

As a result of ovulations and follicular atresia, the number of follicles with oocytes decreases over time, leading to menopause. The ovarian reserve inversely correlates with a woman's age and directly depends on the consequences of surgical interventions on the ovaries and the genetic characteristics of the woman.

HOW CAN THE OVARIAN RESERVE BE MEASURED?

Tests to determine the ovarian reserve include biochemical analyses and ultrasound examinations of the ovaries:
1. Determination of follicle-stimulating hormone (FSH) levels,
- estradiol (E2) or inhibin B in the early follicular phase...
Levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) increase,
while the levels of estradiol 2 and inhibin B in the blood serum decrease.
2. Determination of anti-Müllerian hormone (AMH) levels...

AMH levels,
produced by the early granulosa cells of follicles, are not dependent on gonadotropins or the use of contraceptives...

3. Determination of ovarian reserve using ultrasound includes the calculation of the number of antral follicles (size 2-10 mm) and the measurement of ovarian volume.
4. Tests with provocation by clomiphene citrate or other anti-estrogenic drugs ...
During the process of counseling a couple regarding infertility or patients with menstrual cycle disorders,
an individual examination plan is created ...

Based on the results obtained, more precise treatment recommendations are formed ...