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INDICATIONS
- Treatment of major depressive disorder.
- Treatment of peripheral neuropathic pain in diabetes.
- Treatment of generalized anxiety disorder.
Ezequa is intended for use in adults.
CONTRAINDICATIONS / SIDE EFFECTS
- Hypersensitivity to the active substance or any of the excipients.
- Concurrent use with non-selective and irreversible monoamine oxidase inhibitors (MAOIs) is contraindicated.
- Liver disease with impaired function.
- Concurrent use with fluvoxamine, ciprofloxacin, or enoxacin (potent CYP1A2 inhibitors) is contraindicated due to increased plasma concentration of duloxetine.
- Severe renal impairment (creatinine clearance < 30 ml/min).
- Initiation of treatment is contraindicated in patients with uncontrolled hypertension due to the risk of hypertensive crisis.
DOSAGE
- Major depressive disorder: The recommended initial and maintenance dose is 60 mg once daily, regardless of meals.
- Generalized anxiety disorder: Initial dose is 30 mg once daily, with a possible increase to 60 mg depending on patient response.
- Peripheral neuropathic pain in diabetes: Initial and maintenance dose is 60 mg daily.
SPECIAL INSTRUCTIONS
- Elderly patients: No dose adjustment is required based on age, but caution is advised.
- Patients with liver impairment: Use is contraindicated.
- Patients with renal impairment: No dose adjustment is required for mild to moderate renal impairment.
METHOD OF ADMINISTRATION
For oral use.
The package contains 28 capsules.
- Treatment of major depressive disorder.
- Treatment of peripheral neuropathic pain in diabetes.
- Treatment of generalized anxiety disorder.
Ezequa is intended for use in adults.
CONTRAINDICATIONS / SIDE EFFECTS
- Hypersensitivity to the active substance or any of the excipients.
- Concurrent use with non-selective and irreversible monoamine oxidase inhibitors (MAOIs) is contraindicated.
- Liver disease with impaired function.
- Concurrent use with fluvoxamine, ciprofloxacin, or enoxacin (potent CYP1A2 inhibitors) is contraindicated due to increased plasma concentration of duloxetine.
- Severe renal impairment (creatinine clearance < 30 ml/min).
- Initiation of treatment is contraindicated in patients with uncontrolled hypertension due to the risk of hypertensive crisis.
DOSAGE
- Major depressive disorder: The recommended initial and maintenance dose is 60 mg once daily, regardless of meals.
- Generalized anxiety disorder: Initial dose is 30 mg once daily, with a possible increase to 60 mg depending on patient response.
- Peripheral neuropathic pain in diabetes: Initial and maintenance dose is 60 mg daily.
SPECIAL INSTRUCTIONS
- Elderly patients: No dose adjustment is required based on age, but caution is advised.
- Patients with liver impairment: Use is contraindicated.
- Patients with renal impairment: No dose adjustment is required for mild to moderate renal impairment.
METHOD OF ADMINISTRATION
For oral use.
The package contains 28 capsules.
